The potential for side-effect damage is greatest in the pre-pubescent and younger athlete. Steroids have also been known to reduce libido, produce sterility and in some cases, gynecomastia (male breast development). Vida (1969), in his book Androgens and Anabolic Agents, states, "There are no truly 100 percent anabolic steroids. All have androgenic properties, which create most of the undesirable side effects." Generally, these side effects are reversible upon discontinuance of therapy in normal, healthy individuals. The predominance of steroids in training programs has prompted the American Medical Association committee on medical aspects of sports and other interested groups to oppose their haphazard use in athletics.
The decision to control the use of steroids was taken from the point of view of both athletic ethics and integrity, and the still undetermined long-range effect of their use. III. Comparison of Common Anabolic Agents The anabolic steroids should lack all androgenic properties for most effective clinical use; however, in athletic use androgenicity is useful in certain cases. For our purposes, we will use the anabolic androgenic properties as well as experienced and reported results to compare the commonly used anabolic steroids. Evaluation of biological data comparing the anabolic and androgenic properties of steroids is quite difficult. Androgenicity is usually defined in these studies (Vida, 1969) in the following way: Growth of the seminal vesicles (s.v.) and ventral prostate (v.p.) in rodents, and the growth of the chick and capon comb. Anabolism is defined in humans in the following way:
Anabolic activity is associated with nitrogen retention and positive protein metabolism.
Therefore, the increase in weight of the levator ani (l.a.) muscle of. the rat is the most common index and is termed levator activity or myotrophic activity.
arimidex for sale Therefore, the difference in weight between the seminal vesicles or ventral prostate (s.v. or v.p.) of treated and untreated animals provides a measure of androgenic activity while the difference in weight of the levator ani (l.a.) provides a measure of the anabolic activity of the steroids.
Anabolic activity will be expressed hence as the ratio of the activity of the studied compound to that of testosterone or testosterone propionate (subcutaneous) or methyltestosterone (oral) in increasing the weight of the levator ani muscle of the rat. The standards, testosterone (t), testosterone propionate (tp), and methyltestosterone (mt) are expressed as 100 percent activity.
Androgenicity in kind will relate to the increase in weight of the seminal vesicles or ventral prostate of the rat.
The anabolic-androgenic ratio of Q is expressed as the anabolic activity of the compound compared to t, tp or mt as measured by the present increase in weight of the levator ani muscle in the castrated rat divided by the percent increase in weight of the seminal vesicals or ventral prostate of a castrated rat.